![]() ![]() But acute sinusitis is a temporary infection of the sinuses often associated with a cold. Pain, tenderness and swelling around your eyes, cheeks, nose or foreheadĬhronic sinusitis and acute sinusitis have similar signs and symptoms.Blocked or stuffy (congested) nose causing difficulty breathing through your nose.Drainage down the back of the throat (postnasal drainage).Thick, discolored discharge from the nose (runny nose).Alport syndrome is generally a more serious version of TBMD, and further observation and testing may be done by your doctor to determine which disease you have.Common signs and symptoms of chronic sinusitis include: Both are inherited disorders that mainly affect the glomeruli. TBMD is similar to Alport Syndrome, which is a disease that also involves mutations in type IV collagen genes. However, such mutations are not present in all families. The identified genes are called COL4A3 and COL4A4. If one parent has TBMD, then each child has a 50% chance of getting the disease.Ĭhanges in certain genes (known as mutations) that affect type IV collagen (a protein that is important to the normal structure and function of glomeruli) have been identified in patients with TBMD. In other words, only one copy of the abnormal gene from one of the parents is needed to cause the disease. This disorder is passed from parent to child by autosomal dominant inheritance. How is Thin Basement Membrane Disease Inherited? Reducing dietary salt can also help control swelling.Īlthough rare, dialysis or kidney transplant may be needed if the disease leads to kidney failure. To help with any swelling, your doctor may also prescribe diuretics (water pills). For example, your doctor may prescribe certain medicines that are used to lower blood pressure, but may also help reduce the protein in the urine. Similar treatments that are used in people with high blood pressure and other symptoms of chronic kidney disease (CKD) are used in people with this disease. However, in some cases complications arise and further treatment is required.Ĭurrently there is no specific treatment for TBMD. ![]() In most cases, TBMD has a benign course, meaning that the long-term prognosis for most people are good and people with the disease generally live normal lives. How is Thin Basement Membrane Disease Treated? This disorder produces unique changes in the walls of the blood vessels of the glomeruli that can be detected by electron microscopy of kidney biopsy material. A blood test for serum creatinine can be used to calculate glomerular filtration rate (GFR), which tells how well your kidneys are filtering wastes from the blood.Ī biopsy is usually done to confirm a diagnosis. A urine test can check for the amount of protein, blood and other things to indicate kidney damage. How is Thin Basement Membrane Disease Diagnosed?Ī doctor can test your blood and urine to check if your kidneys are working properly. In most cases, there are no other major symptoms that are observed, but people with TBMD can also have high blood pressure, less urine production and body swelling. Another common symptom is protein in the urine (proteinuria). The main symptom of TBMD is blood in the urine (hematuria). It is a rare disorder that has been diagnosed in less than 1 percent of the population. Thin basement membrane disease (TBMD) is an inherited disorder that mainly affects the glomeruli, which are tiny tufts of capillaries (small blood vessels) in the kidneys that filter wastes from the blood. ![]()
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